Matin-Mann F, Gao Z, Wei C, Repp F, Artukarslan E, John S, Alcacer Labrador D, Lenarz T, Scheper VDevelopment and In-Silico and Ex-Vivo Validation of a Software for a Semi-Automated Segmentation of the Round Window Niche to Design a Patient Specific Implant to Treat Inner Ear Disorders J. Imaging, February 2023

The aim of this study was to develop and validate a semi-automated segmentation approach that identifies the round window niche (RWN) and round window membrane (RWM) for use in the development of patient individualized round window niche implants (RNI) to treat inner ear disorders. Twenty cone beam computed tomography (CBCT) datasets of unilateral temporal bones of patients were included in the study. Defined anatomical landmarks such as the RWM were used to develop a customized 3D Slicer™ plugin for semi-automated segmentation of the RWN


Title for This Block Mau R, Schick P, Matin-Mann F, Gao Z, Alcacer Labrador D, John S, Repp F, Lenarz T, Weitschies W, Scheper V, Seidlitz A, Seitz H. Digital light processing and drug stability of Dexamethasone-loaded implant prototypes for medical treatment of the inner ear Transactions on Additive Manufacturing Meets Medicine, September 2022

3D printed, patient-individualized drug-eluting implants for the round window niche (RWN) are an innovative, minimally invasive concept for the medical treatment of inner ear disorders. In this study, we investigate the 3D printing via digital light processing (DLP) and the long-term drug stability of Dexamethasone(DEX)-loaded implant prototypes (storage of 12 months at 25 °C/60 % relative humidity and 40 °C/75 % relative humidity (“accelerated”)

Mau R, Nazir J, Gao Z, Alcacer Labrador D, Repp F, John S, Lenarz T, Scheper V, Seitz H, Matin-Mann F. Digital Light Processing of Round Window Niche Implant Prototypes for Implantation Studies Current Directions in Biomedical Engineering, September 2022

A new approach that offers the potential for local drug delivery to the inner ear is a 3D printed, patient individualized, drug-loaded implant that precisely fits into the round window niche (RWN). Anatomically correct digital light processing (DLP) 3D printed implant prototypes are beneficial for preoperative planning and rehearsal of implantation techniques due to tactile feedback. The aim is to define desired mechanical material properties for future RWN implants

Matin-Mann F, Gao Z, Schwieger J, Ulbricht M, Domsta V, Senekowitsch S, Weitschies W, Seidlitz A, Doll K, Stiesch M, Lenarz T, Scheper VIndividualized, Additively Manufactured Drug-Releasing External Ear Canal Implant for Prevention of Postoperative Restenosis: Development, In Vitro Testing, and Proof of Concept in an Individual Curative Trial Pharmaceutics, June 2022

Postoperative restenosis in patients with external ear canal (EEC) atresia or stenosis is a common complication following canaloplasty. Our aim in this study was to explore the feasibility of using a three dimensionally (3D)-printed, patient-individualized, drug ((dexamethasone (DEX)), and ciprofloxacin (cipro))-releasing external ear canal implant (EECI) as a postoperative stent after canaloplasty


Gao Z, Schwieger J, Matin-Mann F, Behrens P, Lenarz T, Scheper VDexamethasone for Inner Ear Therapy: Biocompatibility and Bio-Efficacy of Different Dexamethasone Formulations In Vitro Biomolecules, December 2021

Dexamethasone is widely used in preclinical studies and clinical trials to treat inner ear disorders. The results of those studies vary widely, maybe due to the different dexamethasone formulations used. Laboratory (lab) and medical grade (med) dexamethasone (DEX, C22H29FO5) and dexamethasone dihydrogen phosphate-disodium (DPS, C22H28FNa2O8P) were investigated for biocompatibility and bio-efficacy in vitro

Gao Z, Matin-Mann F, Wei C, Lenarz T, Weber C, John S, Scheper V3D Printed Individualized Frontal Neo-Ostium Implant in Endoscopic Sinus Surgery – a Proof of Concept Study Current Directions in Biomedical Engineering, December 2021

3D-printing paves the way forpersonalized drug therapyvia implantsindividualized for the patient specific anatomy in chronic paranasal sinus diseases.This study bringstogether the workflowof modeling, manufacturing, and sterilization of3D-printed individualized frontal neo-ostium implants(FOI)for optimization of Endoscopic Sinus Surgery (ESS)and validates the implantability of the printed devices

Mau R, Jüttner G, Gao Z, Matin F, Alcacer Labrador D, Repp F, John S, Scheper V, Lenarz T, Seitz H. Micro injection molding of individualised implants using 3D printed molds manufactured via digital light processing Current Directions in Biomedical Engineering, December 2021

Here, we demonstrate a manufacturing process for individualised, small-sized implant prototypes. Our process is promising for the manufacturing of drug-releasing (micro)implants to be implanted in the round window niche (RWN-I, solid body, free-form-shaped design, 1.1 x 2.7 x 3.1 mm) and for frontal neo-ostium implants (FO-I, tube-like design, length ~ 7 mm, Ø ~ 2–6 mm) for frontal sinus drainage. Implant prototypes are manufactured using micro injection molding (μIM)

Matin F, Gao Z, Bronzlik P, Lenarz T, Scheper VA 3D printed patient specific artificial outer ear model for use in auricle reconstruction surgery: a clinical feasibility study Transactions on Additive Manufacturing Meets Medicine, Vol 3 No 1 (2021)

Auricle reconstruction is a routine surgery in the field of Otolaryngology but the design of the reconstruction is based on the clinicians guess of the correct previous anatomy. Using additive manufacturing processes to build a model the surgeon can refer to may be a good substitute for conventional surgery

Mau R, Jüttner G, Gao Z, Matin F, Alcacer Labrador D, Repp F, John S, Scheper V, Lenarz T, Seitz H. Rapid tooling for micro injection molding of micro medical devices via digital light processing Transactions on Additive Manufacturing Meets Medicine, Vol 3 No 1 (2021)

High-resolution additive manufacturing methods such as digital light processing (DLP) offer promising opportunities for rapid tooling for micro injection molding (µIM). There are possible savings in time and costs for µIM of small and micro plastic parts for sensors, electronics and (bio)medical products

Modern therapy of inner ear disorders is increasingly shifting to local drug delivery using a growing number of pharmaceuticals. Access to the inner ear is usually made via the round window membrane (RWM), located in the bony round window niche (RWN). We hypothesize that the individual shape and size of the RWN have to be taken into account for safe reliable and controlled drug delivery

Schurzig D, Fröhlich M, Raggl S, Scheper V, Lenarz T, Rau TS. Uncoiling the Human Cochlea—Physical Scala Tympani Models to Study Pharmacokinetics Inside the Inner Ear Life, 2021 April 21.

In the field of cochlear implantation, artificial/physical models of the inner ear are often employed to investigate certain phenomena like the forces occurring during implant insertions. Up to now, no such models are available for the analysis of diffusion processes inside the cochlea although drug delivery is playing an increasingly important role in this field


Chronic rhinosinusitis (CRS) is a common disease in the general population that is increasing in incidence and prevalence, severely affecting patients’ quality of life. Medical treatment for CRS includes self-management techniques, topical and oral medical treatments, and functional endoscopic sinus surgery (FESS). FESS is a standard procedure to restore sinus ventilation and drainage by physically enlarging the inflamed sinus passageways

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